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Mortality in patients with permanent hypoparathyroidism after total thyroidectomy
M Almquist1, K Ivarsson2, E Nordenström1
1Department of Surgery, Skåne University Hospital, and Department of Clinical Sciences, Lund University, Lund, Sweden.
The British Journal of Surgery
|April 18, 2018
Summary
Permanent hypoparathyroidism after total thyroidectomy is common and doubles the risk of death. This study investigated long-term mortality in patients with this condition following thyroid surgery.
Area of Science:
- Endocrinology
- Surgical Outcomes
- Public Health
Background:
- Permanent hypoparathyroidism is a frequent complication of total thyroidectomy.
- Long-term health consequences of post-thyroidectomy hypoparathyroidism are not well understood.
Purpose of the Study:
- To determine the mortality risk associated with permanent hypoparathyroidism after total thyroidectomy for benign thyroid disease.
Main Methods:
- Utilized data from Swedish national registers (surgery, prescriptions, inpatient) from 2005-2014.
- Identified patients with permanent hypoparathyroidism (requiring active vitamin D for ≥6 months post-surgery).
- Employed Cox regression to analyze mortality risk, adjusting for covariates.
Main Results:
- The study included 4899 patients; 5.2% developed permanent hypoparathyroidism.
- Over a mean follow-up of 4.4 years, 2.2% of patients died.
- Permanent hypoparathyroidism was linked to a significantly higher risk of death (adjusted hazard ratio 2.09).
Conclusions:
- Permanent hypoparathyroidism is a common adverse outcome following total thyroidectomy for benign conditions.
- This condition is associated with an increased risk of mortality.
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