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Related Experiment Video

Updated: Feb 11, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter-based left atrial appendage closure.

Ketil Lunde, Ahmed Al-Ani, Reidar Bjørnerheim

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |April 18, 2018
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    Summary
    This summary is machine-generated.

    Catheter-based left atrial appendage closure is a feasible stroke prevention method for atrial fibrillation patients unsuitable for anticoagulation. While generally safe, potential complications necessitate careful patient selection.

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    Area of Science:

    • Cardiology
    • Medical Devices
    • Stroke Prevention

    Background:

    • Atrial fibrillation (AF) is a common condition increasing stroke risk.
    • Anticoagulation effectively prevents thromboembolism in AF but is contraindicated for many patients.
    • Left atrial appendage (LAA) occlusion presents a novel stroke prevention strategy for AF.

    Purpose of the Study:

    • To evaluate the feasibility and safety of catheter-based LAA occlusion in high-risk AF patients.
    • To assess procedural success, complications, and clinical outcomes over a one-year follow-up.

    Main Methods:

    • Twenty-seven AF patients with high stroke risk underwent attempted LAA occlusion (Sept 2014 - Apr 2016).
    • Anticoagulation was contraindicated in 26 of the patients.
    • Outcomes assessed included procedural success, echocardiographic findings, and clinical events.

    Main Results:

    • Successful LAA occlusion was achieved in 26 patients.
    • Complications included stroke (1), transfusion-requiring groin bleed (1), and cardiac tamponade (1).
    • One patient not receiving an LAA occlusion device died of stroke; three experienced transient ischemic attacks (TIAs).

    Conclusions:

    • Catheter-based LAA occlusion is a viable procedure for stroke prevention in selected AF patients.
    • The procedure carries risks, including stroke and bleeding, requiring careful consideration.
    • LAA occlusion should be reserved for high-stroke-risk AF patients with contraindications to anticoagulation.