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Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
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Advances in Tumor Targeted Liposomes

A Jain1, Jain2

  • 1Institute of Pharmaceutical Research, GLA University, NH-2, Mathura-Delhi Road, Mathura (U.P.) 281 406, India.

Current Molecular Medicine
|April 18, 2018
PubMed

Insights

Liposomes offer a promising solution for targeted cancer chemotherapy. These nanocarriers can be engineered for enhanced drug delivery, improving treatment efficacy and safety for cancer patients.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Cancer treatment faces challenges in safe and effective drug delivery to tumor cells.
  • The tumor microenvironment is increasingly utilized for targeted chemotherapy.
  • Liposomes are versatile nanocarriers for drug delivery due to their biocompatibility and adaptability.

Purpose of the Study:

  • To review advances in developing liposomes for targeted cancer therapy.
  • To explore strategies for enhancing drug delivery specificity and efficacy.
  • To provide insights for designing novel cancer-targeted liposomes.

Main Methods:

  • Utilizing the Enhanced Permeability and Retention (EPR) effect for passive targeting.
  • Incorporating tumor-selective ligands (e.g., folate, transferrin, peptides) for active targeting.
  • Investigating stimuli-responsive "smart" liposomes triggered by pH, temperature, enzymes, magnetic fields, ultrasound, and redox potential.

Main Results:

  • Surface modification and PEGylation of liposomes reduce immunogenicity and increase target specificity.
  • Targeted liposomes exploit the EPR effect and specific ligands to accumulate at tumor sites.
  • Stimuli-responsive liposomes enable controlled drug release within the tumor microenvironment.

Conclusions:

  • Liposomes represent a significant advancement in targeted cancer drug delivery.
  • Combining EPR effect, active targeting ligands, and stimuli-responsiveness optimizes liposomal drug delivery.
  • This review offers valuable knowledge for researchers and formulators in cancer nanomedicine.
Keywords:
CancerEPR effectPEGylationactive targetinganticancer agentschemotherapyligand.

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