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Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
Published on: August 18, 2016
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Advances in Tumor Targeted Liposomes.
1Institute of Pharmaceutical Research, GLA University, NH-2, Mathura-Delhi Road, Mathura (U.P.) 281 406, India.
Current Molecular Medicine
|April 18, 2018
Summary
Liposomes offer a promising solution for targeted cancer chemotherapy. These nanocarriers can be engineered for enhanced drug delivery, improving treatment efficacy and safety for cancer patients.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer treatment faces challenges in safe and effective drug delivery to tumor cells.
- The tumor microenvironment is increasingly utilized for targeted chemotherapy.
- Liposomes are versatile nanocarriers for drug delivery due to their biocompatibility and adaptability.
Purpose of the Study:
- To review advances in developing liposomes for targeted cancer therapy.
- To explore strategies for enhancing drug delivery specificity and efficacy.
- To provide insights for designing novel cancer-targeted liposomes.
Main Methods:
- Utilizing the Enhanced Permeability and Retention (EPR) effect for passive targeting.
- Incorporating tumor-selective ligands (e.g., folate, transferrin, peptides) for active targeting.
- Investigating stimuli-responsive "smart" liposomes triggered by pH, temperature, enzymes, magnetic fields, ultrasound, and redox potential.
Main Results:
- Surface modification and PEGylation of liposomes reduce immunogenicity and increase target specificity.
- Targeted liposomes exploit the EPR effect and specific ligands to accumulate at tumor sites.
- Stimuli-responsive liposomes enable controlled drug release within the tumor microenvironment.
Conclusions:
- Liposomes represent a significant advancement in targeted cancer drug delivery.
- Combining EPR effect, active targeting ligands, and stimuli-responsiveness optimizes liposomal drug delivery.
- This review offers valuable knowledge for researchers and formulators in cancer nanomedicine.
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