Animal Models of Aspergillosis

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Updated: Feb 11, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.1K

Guillaume Desoubeaux1, Carolyn Cray2

  • 1Department of Pathology and Laboratory Medicine, Division of Comparative Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA; Parasitology-Mycology Service, Tropical Medicine Program, University Hospital of Tours, CEPR - Inserm U1100, Medical Faculty, François Rabelais University, Tours, France.

Comparative Medicine
|April 18, 2018
PubMed

Insights

Aspergillosis, an airborne fungal infection, causes significant illness and death in humans and animals. This review details fungal diseases and experimental animal models, emphasizing standardization needs for reproducible research.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Veterinary Medicine

Background:

  • Aspergillosis is a serious airborne fungal disease caused by Aspergillus species, leading to high morbidity and mortality in humans and animals.
  • The increasing prevalence of this infection necessitates reliable experimental models for comprehensive study.

Purpose of the Study:

  • To review the fungus Aspergillus, associated diseases in humans and animals, and current experimental animal models.
  • To highlight the advantages, limitations, and critical variables affecting aspergillosis models.
  • To emphasize the need for standardization in animal model research for aspergillosis.

Main Methods:

  • Review of existing literature on Aspergillus, aspergillosis, and animal models.
  • Analysis of experimental variables impacting disease course and infection reproducibility.
  • Identification of key areas for standardization in animal model studies.

Main Results:

  • Aspergillus species cause significant health issues in both human and animal populations.
  • Various animal models exist for studying aspergillosis, each with unique benefits and drawbacks.
  • Experimental variables such as species, immunosuppression, infection route, and diagnostics significantly influence model outcomes.

Conclusions:

  • Standardization of animal models is crucial for reproducible and reliable research on aspergillosis.
  • Further research and consensus are needed to establish standardized protocols for aspergillosis animal models.
  • Improved models will facilitate a better understanding of fungal virulence, diagnostics, and antifungal drug development.

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