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Updated: Feb 11, 2026

Use of a Rat Model to Study Ventral Abdominal Hernia Repair
Published on: October 2, 2017
Repair of a Large Ventral Hernia in a Rhesus Macaque (Macaca mulatta) by Using an Abdominal Component Separation
Steve J Kempton1, Jacqueline S Israel2, Saverio Capuano3
1Division of Plastic and Reconstructive Surgery, University of Wisconsin, Madison, Wisconsin, USA.,
Abstract:
Here we present a 32-y-old rhesus macaque (Macaca mulatta) with a large recurrent ventral incisional hernia. The initial surgery included midline celiotomy for treatment of endometriosis, in which the animal developed a hernia that was repaired with interposition of mesh. Hernia recurrence at 1 y resulted in a defect measuring 7 × 13 cm, with loss of abdominal domain. Skin breakdown was noted with areas of exposed mesh through the skin with associated acute on chronic infection. Clinically, the animal was lethargic, not eating, and failing to thrive. The present surgical treatment included midline celiotomy, removal of mesh, and attempted primary fascial closure. Due to the large defect and high tension, the fascia could not be closed. To facilitate closure, abdominal component separation technique was used and consisted of skin and subcutaneous dissection, external oblique muscle release, and dissection between the external and internal oblique musculature. This technique allowed for primary fascial closure and resection of excess diseased skin. A piece of polypropylene mesh was placed in a sublay fashion to reinforce the primary fascial closure. The animal tolerated the procedure well and has demonstrated steady weight gain, with no recurrence at 12 mo. Large ventral abdominal hernia defects in after surgery or trauma in NHP can present reconstructive challenges to veterinary surgeons. Failure to achieve a dynamic, low-tension closure can result in hernia recurrence, necessitating additional operations. Abdominal component separation is not commonly used in veterinary surgery and may be a helpful tool in cases of difficult abdominal reconstructions.
Insights
A rhesus macaque with a large ventral incisional hernia, complicated by infection, was successfully treated using abdominal component separation. This surgical technique facilitated primary fascial closure and mesh reinforcement, preventing recurrence.
Area of Science:
- Veterinary Surgery
- Abdominal Wall Reconstruction
- Non-Human Primate (NHP) Models
Background:
- Recurrent ventral incisional hernias in non-human primates (NHPs) pose significant surgical challenges.
- Previous mesh repair failed, leading to a large defect (7x13 cm) with skin breakdown, exposed mesh, and infection in a rhesus macaque.
Observation:
- The rhesus macaque presented with a large, recurrent ventral incisional hernia, skin breakdown, exposed mesh, and signs of infection.
- Initial attempts at primary fascial closure were unsuccessful due to high tension and the large defect size.
Findings:
- Abdominal component separation, involving external oblique muscle release, enabled tension-free primary fascial closure.
- A polypropylene mesh was placed in a sublay fashion to reinforce the repaired fascia.
- The animal recovered well, showed weight gain, and had no hernia recurrence at 12 months post-surgery.
Implications:
- Abdominal component separation, a technique not commonly used in veterinary surgery, proved effective for complex abdominal wall reconstruction in NHPs.
- This approach offers a viable solution for challenging ventral hernia defects, potentially reducing recurrence rates.
- Successful reconstruction highlights the adaptability of human surgical techniques for NHP models, advancing comparative medicine.
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