Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Finding Electric Potential From Electric Field01:13

Finding Electric Potential From Electric Field

5.7K
For a system of charges, it is easy to calculate the system's potential because potential is a scalar quantity. However, in some instances where calculating the electric field is more straightforward than finding the potential, the electric field is used to calculate the system's potential. For a positive charge, the electric field is radially outward, and the potential is positive at any finite distance from the positive charge. In such an electric field, the motion away from the...
5.7K
Determining Electric Field From Electric Potential01:12

Determining Electric Field From Electric Potential

5.0K
The electric field and electric potential are related to each other. If the electric field at various points in the region of interest is known, it can be used to calculate the electric potential difference between any two points. Similarly, if the electric potential is known for various points, then it is possible to calculate the electric field.
In general, regardless of whether the electric field is uniform, it points in the direction of decreasing potential because the force on a positive...
5.0K
Electric Potential Energy in a Uniform Electric Field01:09

Electric Potential Energy in a Uniform Electric Field

6.5K
When an electric field accelerates a free positive charge, it acquires kinetic energy. This process is analogous to an object being accelerated by a gravitational field as if the charge were going down an electrical hill where its electric potential energy is converted into kinetic energy, although, of course, the sources of the forces are very different. The electrostatic or Coulomb force acting on the positive test charge is conservative, which means that the work done on a test charge is...
6.5K
Electrical Systems01:21

Electrical Systems

770
In electrical engineering, the analysis of networks composed of passive linear components — resistors (R), capacitors (C), and inductors (L) — is fundamental. These components are organized into circuits where the relationship between input and output can be analyzed using transfer functions. The transfer function of an RLC circuit, which relates the voltage across a capacitor to the input voltage, can be derived using Kirchhoff's laws.
To derive the transfer function, consider an RLC...
770
Electric Charges01:11

Electric Charges

23.2K
From lightning during thunderstorms to electronic devices, the phenomenon of electromagnetism is all around us. The electromagnetic force is one of the four fundamental forces of nature. It has been known to humanity in various forms for thousands of years. For example, the ancient Greek philosopher Thales of Miletus recorded his experiments on static electricity using amber and fur in the sixth century BC.
The English physicist William Gilbert studied the phenomenon of static electricity in...
23.2K
Electric Field01:16

Electric Field

12.9K
Consider two point charges, each exerting Coulomb force on the other. It is possible to describe the Coulomb interaction via an intermediate step by defining a new physical quantity called the electric field.
In the new picture, imagine that the first charge sets up an electric field independent of all other charges in the universe. When another charge comes in its vicinity, the second charge experiences an electric force depending on the electric field at that point. The source charge does not...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanowrinkled Interface-Coupled Metaphase Chromosome Spreading and Nanoscale Conformability.

ACS nano·2026
Same author

Wearable Myoelectric Interface for Neurorehabilitation (MINT) to Recover Arm Activity After Stroke: A Randomized Controlled Trial.

Neurorehabilitation and neural repair·2026
Same author

Amplification-free dual-blocking autocatalytic CRISPR-Cascade for attomolar DNA detection with low nonspecific signal.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Kinetic Modeling of Target-Amplification-Free CRISPR-Cas-Based Autocatalysis Reactions.

bioRxiv : the preprint server for biology·2026
Same author

Evolving roles and workforce trends among nurse practitioners in Aotearoa New Zealand (2014-2022).

The New Zealand medical journal·2026
Same author

Interpretability of an FDA-authorized AI/ML sepsis diagnostic tool improved by SHAP values.

JAMIA open·2026

Related Experiment Video

Updated: Feb 11, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K

A microfluidic biochip platform for electrical quantification of proteins.

Enrique Valera1, Jacob Berger, Umer Hassan

  • 1Department of Bioengineering, University of Illinois at Urbana-Champaign, 1270 Digital Computer Laboratory, 1304 W. Springfield Ave., Urbana, Illinois 61801, USA. rbashir@illinois.edu.

Lab on a Chip
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

A novel microfluidic biochip detects Interleukin 6 (IL-6) in plasma for sepsis. This point-of-care technology shows promise for diagnosing and stratifying sepsis progression using immune biomarkers.

More Related Videos

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

12.3K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

17.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K
High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

12.3K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

17.0K

Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Immunology

Background:

  • Sepsis is a life-threatening condition with high mortality and healthcare costs in the US.
  • Immune biomarkers like Interleukin 6 (IL-6) correlate with sepsis onset and progression.
  • Current diagnostic tools lack the ability to stratify sepsis progression using biomarker levels.

Purpose of the Study:

  • To develop and validate a microfluidic biochip platform for detecting protein biomarkers in undiluted human plasma.
  • To assess the potential of this platform as a point-of-care technology for sepsis diagnosis and stratification.

Main Methods:

  • A microfluidic biochip platform integrating Coulter counting principles, antigen-specific capture chambers, and micro-bead immunodetection was developed.
  • The platform was used to quantify Interleukin 6 (IL-6) protein levels in undiluted human plasma samples.
  • Validation involved comparing chip results to control measurements using correlation (R2) and agreement (Bland-Altman) analyses.

Main Results:

  • The microfluidic biochip successfully quantified IL-6 protein from human plasma samples (n=29).
  • A strong correlation (R2 = 0.81) and agreement were observed between the biochip measurements and control values.
  • The platform demonstrated potential as a point-of-care diagnostic tool.

Conclusions:

  • The developed microfluidic biochip platform is a viable technology for detecting protein biomarkers like IL-6 in plasma.
  • This platform shows significant potential for point-of-care sepsis diagnosis and stratification.
  • Future applications may involve simultaneous detection of cell and protein biomarkers for comprehensive sepsis management.