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Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Microfluidics

Background:

  • Positron Emission Tomography (PET) is a key molecular imaging technique for cancer.
  • Gallium-68 (68Ga) is a preferred PET nuclide due to its convenient half-life and cyclotron-independent production.
  • Development of 68Ga-labeled radiotracers for PET cancer imaging is an active research area.

Purpose of the Study:

  • To investigate the feasibility of using a commercially available microfluidic device for synthesizing 68Ga-labeled radiotracers.
  • To evaluate the synthesis parameters and assess the performance of a continuous flow reactor for 68Ga labeling.
  • To demonstrate a proof of principle for microfluidic-based production of important PET imaging agents.

Main Methods:

  • Synthesis of three key 68Ga-labeled radiotracers: [68Ga]Ga-PSMA-11, [68Ga]Ga-NODAGA-RGDyk, and [68Ga]Ga-DOTA-NOC.
  • Utilized a commercially available microfluidic device for automated radiolabeling.
  • Optimized various synthesis parameters and assessed continuous flow reactor feasibility.

Main Results:

  • Successful radiolabeling of all three precursor molecules with 68Ga.
  • Achieved radiochemical yields exceeding 80% for all tested radiotracers.
  • Demonstrated the suitability of the microfluidic setup for efficient 68Ga tracer production.

Conclusions:

  • Microfluidic synthesis is a viable and efficient method for producing 68Ga-labeled radiotracers for PET imaging.
  • This approach offers a promising alternative for on-demand, automated production of diagnostic agents.
  • The study validates the use of microfluidic devices in advancing radiopharmaceutical production for molecular imaging.