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A comprehensive meta-analysis of stem cell therapy for chronic angina

Rahman Shah1, Samuel B Latham1, Sajjad A Khan2

  • 1Department of Internal Medicine, University of Tennessee, Memphis, Tennessee.

Clinical Cardiology
|April 18, 2018
PubMed

Insights

Stem cell therapy offers significant benefits for patients with chronic angina, improving symptoms and exercise capacity. While effective for angina, it did not impact mortality in this meta-analysis of randomized controlled trials.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Clinical Trials

Background:

  • Many patients with coronary artery disease and refractory angina do not achieve full revascularization or symptom relief with optimal medical therapy.
  • Stem cell therapy presents a promising therapeutic avenue for managing chronic angina.
  • Previous studies on stem cell therapy for angina were limited by small sample sizes and insufficient statistical power.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of stem cell therapy in patients with chronic angina.
  • To provide a robust assessment of stem cell therapy's impact on clinical outcomes in this patient population.

Main Methods:

  • A systematic search of scientific databases and websites was performed to identify relevant RCTs.
  • Data from 10 RCTs, involving a total of 658 patients, were independently collected and analyzed.
  • Consensus was used to resolve any discrepancies in data collection.

Main Results:

  • Stem cell therapy significantly improved Canadian Cardiovascular Society angina class (RR: 1.53, P=0.013) and exercise capacity (SMD: 0.56, P=0.001).
  • Left ventricular ejection fraction (SMD: 0.63, P=0.001) and myocardial perfusion (SMD: -0.70, P=0.001) were enhanced, while anginal episodes decreased (SMD: -1.21, P=0.045).
  • No significant improvement in all-cause mortality was observed during the follow-up period.

Conclusions:

  • Stem cell therapy effectively improves symptoms, exercise tolerance, and cardiac function in patients with chronic angina receiving optimal medical care.
  • The findings suggest that stem cell therapy is a viable option for managing chronic angina.
  • Larger clinical trials are recommended to further validate these positive outcomes and assess long-term effects.
Abstract

Keywords:
AnginaCell TherapyStem Cell

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