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Updated: Feb 11, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Ultrathin Chiral Metal-Organic-Framework Nanosheets for Efficient Enantioselective Separation
Jun Guo1,2,3, Yin Zhang1,2,3, Yanfei Zhu1,3
1CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Abstract:
Chiral metal-organic framework (CMOF) nanosheets only a few layers thick remain a virgin land waiting for exploration. Herein, the first examples of ultrathin CMOF nanosheets are prepared by the confinement growth of two-dimensional (2D) chiral layers, which are assembled by helical metal-organic chains within microemulsion. This convenient and easily scaled up inverse microemulsion method gives a series of 2D CMOF nanosheets composed of variable metal nodes or chiral ligands. More significantly, thanks to the exceptionally large number of chiral sites exposed on surfaces, the as-obtained CMOF nanosheets exhibit much higher enantioselectivity in chiral separation compared with their bulk counterparts.
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