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Related Concept Videos

Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.0K

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Immunological memory: What's in a name?

Thomas Pradeu1, Louis Du Pasquier2

  • 1ImmunoConcept, CNRS & University of Bordeaux, Bordeaux, France.

Immunological Reviews
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Immunological memory, found across diverse life forms, is a complex, multidimensional phenomenon. Understanding this concept is crucial for advancing immunology and developing new therapies.

Keywords:
evolutioninnate immunitylymphocytesprimingsomatic recombinationtrained immunity

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Area of Science:

  • Immunology
  • Evolutionary immunology
  • Cellular immunology

Background:

  • Immunological memory is a central concept in immunology, but its definition and scope are debated.
  • Recent studies suggest immunological memory exists beyond vertebrates, in "innate" immune cells and various phyla.
  • Concepts like "innate immune memory" and "trained immunity" have emerged to explain these broader phenomena.

Purpose of the Study:

  • To critically review and analyze recent claims regarding immunological memory in diverse organisms and cell types.
  • To differentiate between immunological memory, adaptive immunity, and specificity.
  • To highlight the experimental and therapeutic implications of a nuanced view of immunological memory.

Main Methods:

  • Critical literature review and conceptual analysis.
  • Examination of evidence for immunological memory in invertebrates, plants, bacteria, and archaea.
  • Distinguishing between memory, specificity, and adaptive immunity.

Main Results:

  • Immunological memory is a gradual and multidimensional phenomenon, not a simple dichotomy.
  • Claims of "innate immune memory" and "trained immunity" require careful conceptual distinction from adaptive memory.
  • The scope of immunological memory extends beyond vertebrates and adaptive immune cells.

Conclusions:

  • A broader, more nuanced understanding of immunological memory is essential.
  • This expanded view has significant implications for experimental design and therapeutic strategies in immunology.
  • Re-evaluating immunological memory across phyla and cell types offers new insights into immune system evolution and function.