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Area of Science:

  • Reproductive biology
  • Embryology
  • Genetics

Background:

  • Time-lapse technology provides detailed human embryo development data beyond static observations.
  • Morphokinetic parameters are studied for implantation, blastocyst development, and ploidy status prediction.
  • Existing research on morphokinetics and ploidy shows conflicting predictive abilities.

Purpose of the Study:

  • To update on time-lapse morphokinetic assessment for embryo ploidy status.
  • To highlight the impact of patient and ovarian stimulation factors on embryo kinetics.
  • To discuss the potential of embryos with irregular development to achieve euploidy and pregnancy.

Main Methods:

  • Review of current literature on time-lapse imaging and embryo ploidy.
  • Analysis of morphokinetic variables and their correlation with ploidy status.
  • Exploration of clustered data analysis for embryo kinetics.

Main Results:

  • Embryo kinetics are influenced by patient and ovarian stimulation factors, necessitating clustered data analysis.
  • Some embryos with irregular developmental patterns can develop into euploid blastocysts.
  • Current morphokinetic parameters have limitations in accurately predicting ploidy status.

Conclusions:

  • Clustered data analysis is more appropriate for assessing embryo kinetics due to influencing factors.
  • Embryos with atypical development should not be automatically excluded as they can lead to viable pregnancies.
  • Further research is needed to refine the predictive ability of morphokinetics for embryo ploidy.