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Updated: Feb 11, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
Application of lectin microarrays for the analysis of seminal plasma glycome
J Kołodziejczyk1, O Blixt2, B Olejnik1
1Department of Chemistry and Immunochemistry, Medical University of Wrocław, Wrocław, Poland.
Abstract:
We report application of lectin microarrays, exploiting simultaneous interaction of seminal plasma samples with multiple lectins of different sugar specificities to compare the glycomes of fertile and infertile men. The results indicate reduced lectin reactivity associated with decreased fertility, especially affecting oligozoospermic subjects and probably O-glycosylation. Lectin microarrays may become a potent tool for semen analysis in search of the association of glycosylation and male fertility.
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