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Risk factors for late-onset hypogonadism.

Q T Yang1,2, K S Wu1, Z J Li3

  • 1Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Andrologia
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Age, increased waist circumference, high blood pressure, and elevated glucose levels are key risk factors for late-onset hypogonadism (LOH). These findings help identify men at risk for LOH.

Keywords:
ageglucoselate-onset hypogonadismsystolic blood pressure

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Area of Science:

  • Andrology
  • Endocrinology
  • Men's Health

Background:

  • The European Male Aging Study (EMAS) established diagnostic criteria for late-onset hypogonadism (LOH), including serum total testosterone (TT), free testosterone (FT), and sexual symptoms.
  • Risk factors for LOH using these specific EMAS criteria have not been extensively reported.

Purpose of the Study:

  • To investigate the risk factors associated with late-onset hypogonadism (LOH) in adult men based on the established EMAS diagnostic criteria.
  • To identify clinical and biochemical parameters that predict the presence of LOH.

Main Methods:

  • A cohort of 277 men aged 36-80 years underwent health check-ups and completed questionnaires on health, lifestyle, and sexual function.
  • Serum total testosterone (TT) and sex hormone-binding globulin (SHBG) were measured; free testosterone (FT) was calculated. Clinical data including systolic blood pressure (SBP), glucose, and waist circumference were collected.

Main Results:

  • Significant differences in TT, FT, age, waist circumference, SBP, and glucose were observed between LOH-positive and LOH-negative individuals.
  • Univariate regression analysis identified age, waist circumference, SBP, glucose, and general health status as significant risk factors for LOH.
  • Pearson's correlation analysis showed inverse correlations between TT and waist circumference, glucose, and SBP, and between FT and age, SBP, and health status.

Conclusions:

  • Age, increased waist circumference, elevated systolic blood pressure (SBP), and higher glucose levels are identified as significant risk factors for late-onset hypogonadism (LOH).
  • These factors are crucial for identifying men at risk of developing LOH and may inform preventative strategies.