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Updated: Feb 11, 2026

Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
A White Light-Emitting Quantum Dot Complex for Single Particle Level Interaction with Dopamine Leading to Changes in
Sabyasachi Pramanik1, Satyapriya Bhandari2, Uday Narayan Pan1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Abstract:
The interaction of the neurotransmitter dopamine is reported with a single particle white light-emitting (WLE) quantum dot complex (QDC). The QDC is composed of yellow emitting ZnO quantum dots (Qdots) and blue emitting Zn(MSA)2 complex (MSA = N-methylsalicylaldimine) synthesized on their surfaces. Sensing is achieved by the combined changes in the visual luminescence color from white to blue, chromaticity color coordinates from (0.31, 0.33) to (0.24, 0.23) and the ratio of the exponents (αon /αoff ) of on/off probability distribution (from 0.24 to 3.21) in the blinking statistics of WLE QDC. The selectivity of dopamine toward ZnO Qdots, present in WLE QDC, helps detect ≈13 dopamine molecules per Qdot. Additionally, the WLE QDC exhibits high sensitivity, with a limit of detection of 3.3 × 10-9 m (in the linear range of 1-100 × 10-9 m) and high selectivity in presence of interfering biological species. Moreover, the single particle on-off bilking statistics based detection strategy may provide an innovative way for ultrasensitive detection of analytes.
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