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Related Experiment Video

Updated: Feb 11, 2026

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
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Degradable 3D-Printed Hydrogels Based on Star-Shaped Copolypeptides.

Robert Murphy1, David P Walsh2, Charles A Hamilton3

  • 1Department of Chemistry , Royal College of Surgeons in Ireland (RCSI) , 123 St. Stephens Green , Dublin 2 , Ireland.

Biomacromolecules
|April 18, 2018
PubMed
Summary

We developed a novel star copolypeptide hydrogel ink for 3D printing intricate microstructures. This self-healing material enables the creation of stable, degradable scaffolds for potential biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Developing advanced materials for 3D printing is crucial for creating complex biological scaffolds.
  • Hydrogel inks require specific properties like shear-thinning and self-recovery for successful extrusion-based printing.
  • Biocompatibility and controlled degradation are essential for in vivo applications of printed constructs.

Purpose of the Study:

  • To present a star copolypeptide-based hydrogel ink for 3D extrusion printing.
  • To demonstrate the material's suitability for microfabrication of structurally stable scaffolds.
  • To evaluate the biocompatibility and cargo release properties of the printed hydrogel constructs.

Main Methods:

  • Synthesis of an amphiphilic block copolymer: poly(benzyl-l-glutamate)-b-oligo(l-valine).
  • Characterization of hydrogel formation via hydrophobic interactions and self-recovery behavior.
  • 3D extrusion printing of microstructures followed by UV-triggered fixation.
  • Assessment of construct degradability, molecular cargo release, and cytocompatibility with Balb/3T3 cells.

Main Results:

  • The star copolypeptide ink demonstrated excellent printability and structural integrity after extrusion due to self-recovery.
  • UV-triggered fixation resulted in stable hydrogel constructs.
  • The printed scaffolds were degradable, showed favorable cargo release kinetics, and were cytocompatible with Balb/3T3 cells (without reactive diluents).

Conclusions:

  • Star copolypeptide hydrogel inks are suitable for 3D extrusion printing of intricate microstructures.
  • This technology provides a versatile platform for rapid prototyping and development of complex scaffolds.
  • The material's properties support potential applications in tissue engineering and drug delivery systems.