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Biosynthesis of Polysaccharides01:26

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Maca polysaccharides: Extraction optimization, structural features and anti-fatigue activities.

Yujuan Li1, Yizhou Xin2, Fangxue Xu1

  • 1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China.

International Journal of Biological Macromolecules
|April 18, 2018
PubMed
Summary
This summary is machine-generated.

Maca polysaccharides (MCP) were extracted using response surface methodology (RSM), showing significant anti-fatigue activity in low-dose groups. This research optimizes extraction and confirms MCP

Keywords:
Anti-fatigueMaca polysaccharidesOptimizationStructural features

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Natural Products Chemistry

Background:

  • Maca (Lepidium meyenii) is a plant with traditional uses for energy and vitality.
  • Polysaccharides are complex carbohydrates with diverse biological activities.
  • Understanding extraction and bioactivity of maca polysaccharides (MCP) is crucial for its application.

Purpose of the Study:

  • To optimize the extraction conditions for maca polysaccharides (MCP) using response surface methodology (RSM).
  • To investigate the anti-fatigue activity of the extracted MCP.
  • To characterize the composition of the isolated maca polysaccharides.

Main Methods:

  • Response surface methodology (RSM) was employed to determine optimal extraction parameters.
  • Gas chromatography (GC) was used to analyze the monosaccharide composition.
  • Anti-fatigue activity was assessed through swimming tests and biochemical markers (liver glycogen, blood urea nitrogen, lactic acid).

Main Results:

  • Optimal extraction conditions yielded 9.97 mg/g of maca polysaccharides.
  • The isolated MCP had a total sugar purity of 61.00% and protein purity of 4.46%.
  • Monosaccharide analysis revealed a composition of rhamnose, glucose, and galactose in a specific ratio, with low-dose MCP demonstrating significant anti-fatigue effects.

Conclusions:

  • Response surface methodology effectively optimized maca polysaccharide extraction.
  • Maca polysaccharides exhibit notable anti-fatigue properties, particularly at lower doses.
  • The findings support the use of MCP as a potential natural anti-fatigue agent.