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10-year CVD risk in Han Chinese mainland patients with schizophrenia

Shuai Zhao1, HaiLong Xia2, JingJing Mu3

  • 1Department of Psychiatry, Anhui Psychiatric Center, Anhui Medical University, Hefei, Anhui, PR China; Department of Psychiatry, Chao Hu Hospital of Anhui Medical University, Chaohu, Anhui, PR China.

Psychiatry Research
|April 18, 2018
PubMed

Insights

Schizophrenia patients face higher cardiovascular disease (CVD) risk, especially males. This study highlights elevated CVD risk factors in Chinese schizophrenia patients, urging clinical attention.

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • Schizophrenia is linked to reduced life expectancy, primarily due to cardiovascular disease (CVD).
  • Understanding CVD risk factors in schizophrenia is crucial for targeted interventions.

Purpose of the Study:

  • To compare 10-year CVD risk and associated factors between Chinese schizophrenia patients and healthy controls.
  • To identify specific risk factors contributing to elevated CVD risk in this population.

Main Methods:

  • Recruitment of 466 schizophrenia inpatients and 507 healthy community controls in Chinese mainland.
  • Collection of sociodemographic, medical, and smoking history data.
  • Analysis of lipid profiles (TC, HDL-C), fasting blood glucose (FBG), and triglycerides (TG); calculation of 10-year CVD risk (Framingham Risk Score - FRS).

Main Results:

  • Schizophrenia patients exhibited significantly higher 10-year CVD risk than controls.
  • Elevated CVD risk factors in patients included higher BMI, TG, and smoking prevalence; lower FBG and HDL-C.
  • Male schizophrenia patients had higher FRS than females; smoking was associated with FRS in patients.

Conclusions:

  • Han Chinese mainland patients with schizophrenia have a substantial 10-year CVD risk, particularly males.
  • CVD prevention and management in schizophrenia patients require enhanced clinical and research focus.

Keywords:
Cardiovascular diseaseFramingham risk scoreSchizophrenia

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