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Updated: Feb 11, 2026

Primary Culture of Human Vestibular Schwannomas
Published on: July 20, 2014
A novel technique to identify the nerve of origin in head and neck schwannomas
H H Ching1, A G Spinner1, N H Reeve1
1Department of Otolaryngology - Head and Neck Surgery,University of Nevada Las Vegas School of Medicine,USA.
Objective:
Identifying the nerve of origin in head and neck schwannomas is a diagnostic challenge. Surgical management leads to a risk of permanent deficit. Accurate identification of the nerve would improve operative planning and patient counselling.
Methods:
Three patients with head and neck schwannomas underwent a diagnostic procedure hypothesised to identify the nerve of origin. The masses were infiltrated with 1 per cent lidocaine solution, and the patients were observed for neurological deficits.
Results:
All three patients experienced temporary loss of nerve function after lidocaine injection. Facial nerve palsy, voice changes with documented unilateral same-side vocal fold paralysis, and numbness in the distribution of the maxillary nerve (V2), respectively, led to a likely identification of the nerve of origin.
Conclusion:
Injection of lidocaine into a schwannoma is a safe, in-office procedure that produces a temporary nerve deficit, which may enable accurate identification of the nerve of origin of a schwannoma. Identifying the nerve of origin enhances operative planning and patient counselling.
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