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Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2

Gabriel Carmona-Rosas1, Rocío Alcántara-Hernández1, David Alejandro Hernández-Espinosa1

  • 1Instituto de Fisiología Celular (UNAM), México City, 04510, Mexico.

European Journal of Cell Biology
|April 19, 2018
PubMed

Insights

G protein-coupled receptors (GPCRs) are vital drug targets that regulate cell functions. This review analyzes the GPCR-β-arrestin-ERK1/2 signaling module involved in diverse cellular processes.

Area of Science:

  • Cellular Biology
  • Molecular Pharmacology
  • Signal Transduction

Background:

  • G protein-coupled receptors (GPCRs) are crucial regulators of physiological processes.
  • GPCRs are implicated in numerous diseases and are targets for ~25% of marketed drugs.
  • GPCR activation initiates signaling cascades affecting gene transcription, survival, proliferation, and differentiation.

Purpose of the Study:

  • To analyze the signaling characteristics of the GPCR-β-arrestin-ERK1/2 multi-protein complex.
  • To explore the molecular and physiological roles of this signaling module in various cellular contexts.

Main Methods:

  • Literature review of studies on GPCRs, β-arrestins, and ERK1/2 signaling.
  • Analysis of molecular interactions within the GPCR-β-arrestin-ERK1/2 complex.
  • Examination of cellular events mediated by this signaling module.

Main Results:

  • GPCRs form distinct signaling modules with β-arrestins and ERK1/2 pathway components.
  • This complex mediates diverse cellular responses, including gene transcription and cell fate decisions.
  • The interplay within the GPCR-β-arrestin-ERK1/2 complex is critical for cellular function.

Conclusions:

  • The GPCR-β-arrestin-ERK1/2 module represents a significant signaling pathway with broad biological implications.
  • Understanding this module offers insights into disease mechanisms and therapeutic strategies.
  • Further research into this complex is warranted due to its multifaceted roles.
Keywords:
Extracellular signal-regulated kinases 1/2 (ERK1/2)G proteinG protein-coupled receptors (GPCRs)Multi-Protein complexPhosphorylationβ-arrestin

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