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Toxicity of trimetrexate on hemopoietic progenitor cells in normal mice
G V Bogliolo1, R A Lerza, M P Mencoboni
1Patologia Speciale Medica B, University of Genoa, Italy.
Anticancer Research
|March 1, 1988
Abstract:
Single increasing doses of methotrexate (MTX) and trimetrexate (TMQ) were administered to normal mice. Survival of hemopoietic progenitor cells assayed as CFU-S and GM-CFC was determined 24 hr after drug injection. The survival of each population in TMQ-treated animals was not statistically different from that observed in mice treated with MTX. No difference was observed in time-survival curves of hemopoietic progenitor cells comparing TMQ to MTX. TMQ toxicity at the hematological level thus seems comparable to that of MTX.