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Setting a Successful Sorting for Extracellular Vesicle Isolation
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ESCRT-mediated sorting and intralumenal vesicle concatenation in plants
Marisa S Otegui1,2,3
1Department of Botany, University of Wisconsin-Madison, 430 Lincoln Drive, Madison, WI 53706, U.S.A. otegui@wisc.edu.
Biochemical Society Transactions
|April 19, 2018
Summary
Plant cells use the endosomal sorting complex required for transport (ESCRT) machinery to degrade membrane proteins. This review covers plant ESCRT components, their evolution, and novel vesicle formation mechanisms.
Area of Science:
- Cell Biology
- Molecular Biology
- Plant Science
Background:
- Membrane protein degradation requires sorting at endosomes for vacuolar delivery.
- The endosomal sorting complex required for transport (ESCRT) machinery mediates this process.
- Plants possess both conserved and unique ESCRT components.
Purpose of the Study:
- To review characterized plant ESCRT components.
- To discuss the evolutionary diversification of plant ESCRT machinery.
- To highlight recent findings on plant endosomal intralumenal vesicle formation.
Main Methods:
- Literature review of plant ESCRT research.
- Analysis of evolutionary relationships of ESCRT subunits.
- Discussion of a recent study on vesicle budding and fission.
Main Results:
- Identified conserved and plant-specific ESCRT subunits in plants.
- Detailed the roles of characterized plant ESCRT components.
- Presented evidence for concatenated vesicle buds and uncoupled membrane fission.
Conclusions:
- Plant ESCRT machinery is crucial for membrane protein degradation.
- Evolution has shaped plant-specific ESCRT functions.
- Novel mechanisms of intralumenal vesicle formation are emerging in plants.
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