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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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From Localized Scleroderma to Systemic Sclerosis: Coexistence or Possible Evolution.

Dilia Giuggioli¹, Michele Colaci¹, Emanuele Cocchiara¹

¹Scleroderma Unit, Chair of Rheumatology, University of Modena and Reggio Emilia, Modena, Italy.

Dermatology Research and Practice

|April 19, 2018

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) and localized scleroderma (LoS) can coexist. Some LoS patients may develop SSc, especially those with autoantibodies or Raynaud

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Area of Science:

Rheumatology
Dermatology
Autoimmune Diseases

Background:

Systemic sclerosis (SSc) and localized scleroderma (LoS) are distinct conditions.
These diseases may share overlapping features, necessitating investigation into their relationship.
Previous observations suggest potential links, particularly in pediatric cases.

Purpose of the Study:

To evaluate the coexistence of SSc and LoS in a cohort of SSc patients.
To identify potential risk factors or preceding conditions for developing both diseases.

Main Methods:

Retrospective analysis of clinical records from 330 patients diagnosed with SSc.
Identification of patients with a documented history of both LoS and SSc.
Assessment of the temporal relationship and presence of specific biomarkers.

Main Results:

Eight (2.4%) female SSc patients had a history of LoS.
Six of these patients developed LoS before SSc, with 4/6 showing autoantibodies prior to SSc diagnosis.
The median time between LoS and SSc diagnosis was 18 months.

Conclusions:

Systemic sclerosis and localized scleroderma are distinct but can coexist.
Adults with LoS may develop SSc, particularly if they have Raynaud's phenomenon or antinuclear antibodies.
Early identification of these markers in LoS patients could aid in predicting SSc onset.