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Updated: Feb 11, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
Published on: May 2, 2025
Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells
Elizabeth A LaMarca1,2,3,4, Samuel K Powell1,2,3,5, Schahram Akbarian1,2,3
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Abstract:
Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional "mini-brains" and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson's disease, and consider the future of this groundbreaking research.
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