Related Experiment Video
Updated: Feb 11, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Cardiac Output Monitoring in Preterm Infants
Matthew McGovern1,2, Jan Miletin1,3,4,5
1Neonatology Department, Coombe Women and Infant University Hospital, Dublin, Ireland.
Insights
Monitoring cardiac output (CO) in preterm infants is crucial for preventing organ damage and improving outcomes. This review examines current CO monitoring technologies, their limitations, and future directions in neonatal care.
Area of Science:
- Neonatal Medicine
- Cardiovascular Physiology
- Medical Technology
Background:
- Optimal circulatory status is vital for preterm neonates.
- Low cardiac output (CO) in preterm infants causes poor organ perfusion, increasing morbidity, mortality, and adverse neurodevelopmental outcomes.
- Monitoring CO aids in early detection and intervention for reduced organ perfusion.
Purpose of the Study:
- To review current methodologies for monitoring cardiac output in preterm neonates.
- To discuss the relative merits and limitations of existing CO monitoring techniques.
- To identify challenges and knowledge gaps in CO monitoring for this population.
Main Methods:
- Review of existing literature on cardiac output monitoring in preterm neonates.
- Analysis of common technologies used for CO monitoring.
- Discussion of clinical decision-making adjuncts and their imperfections.
Main Results:
- Various technologies exist for CO monitoring in preterm infants, each with advantages and disadvantages.
- No single technique is perfect for monitoring CO in this vulnerable population.
- Clinical decision-making is aided by these technologies, but limitations persist.
Conclusions:
- Ongoing challenges and knowledge gaps exist in monitoring preterm neonatal CO.
- Emerging technologies offer potential improvements in CO monitoring.
- Further research is warranted to advance CO monitoring in preterm infants.
Abstract:
Maintaining optimal circulatory status is a key component of preterm neonatal care. Low-cardiac output (CO) in the preterm neonate leads to inadequate perfusion of vital organs and has been linked to a variety of adverse outcomes with heightened acute morbidity and mortality and adverse neurodevelopmental outcomes. Having technology available to monitor CO allows us to detect low-output states and potentially intervene to mitigate the unwanted effects of reduced organ perfusion. There are many technologies available for the monitoring of CO in the preterm neonatal population and while many act as useful adjuncts to aid clinical decision-making no technique is perfect. In this review, we discuss the relative merits and limitations of various common methodologies available for monitoring CO in the preterm neonatal population. We will discuss the ongoing challenges in monitoring CO in the preterm neonate along with current gaps in our knowledge. We conclude by discussing emerging technologies and areas that warrant further study.
Related Concept Videos
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...
Regulation of Water Output

