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Updated: Feb 11, 2026
09:13
Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
Published on: January 17, 2019
7.9K
Cancer telomeres and white crows.
Alan K Meeker1,2,3,4
1The Department of Pathology, Johns Hopkins School of MedicineBaltimore, MD, USA.
American Journal of Clinical and Experimental Urology
|April 19, 2018
Summary
Research on prostate cancer reveals abnormalities in telomere biology and androgen-regulated telomerase activity. Telomere length measurements may aid in risk assessment and prognosis for prostate cancer patients.
Area of Science:
- Oncology
- Urology
- Molecular Biology
Background:
- Prostate cancer research has investigated telomere and telomerase biology.
- Prostate cancer and its precursor, prostatic intraepithelial neoplasia (PIN), exhibit telomere biology abnormalities.
- Telomerase activity in the prostate is regulated by androgens.
Purpose of the Study:
- To review past and present prostate-focused research on telomere and telomerase biology.
- To highlight discoveries and potential roles of telomerase in prostate epithelial stem cells.
- To discuss the utility of telomere length measurements as prognostic biomarkers.
Main Methods:
- Review of historical and current research findings.
- Analysis of telomere and telomerase biology in prostate cancer and PIN.
- In situ telomere length measurements in patient tissue specimens.
Main Results:
- Abnormalities in telomere biology are associated with prostate cancer and PIN.
- Telomerase activity in the prostate is regulated by androgens.
- In situ telomere length measurements show potential as prognostic biomarkers for risk assessment.
Conclusions:
- Telomere and telomerase research has advanced understanding of prostate cancer.
- Telomere length may serve as a valuable biomarker for prostate cancer prognosis.
- Mentorship and collaborative research foster scientific discovery in urologic oncology.
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