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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
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[Complex regional pain syndrome (CRPS) : An update]
1Klinik und Poliklinik für Neurologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55101, Mainz, Deutschland. violeta.dimova@unimedizin-mainz.de.
Schmerz (Berlin, Germany)
|April 19, 2018
Summary
Complex Regional Pain Syndrome (CRPS) involves immune activation and central nervous system changes. Multidisciplinary, stage-adapted treatment is crucial for improving prognosis and managing persistent pain.
Area of Science:
- Pain Medicine
- Neurology
- Immunology
Background:
- Complex Regional Pain Syndrome (CRPS) involves acute inflammatory responses and develops central nervous system symptoms.
- Psychological factors like anxiety and trauma can negatively impact CRPS treatment outcomes.
- Persistent pain in CRPS often remains even after visible inflammatory symptoms subside.
Purpose of the Study:
- To outline the pathophysiological characteristics of CRPS.
- To emphasize the need for stage-adapted, targeted treatment strategies.
- To detail effective multidisciplinary treatment approaches for CRPS.
Main Methods:
- Pharmacotherapy including steroids, bisphosphonates, dimethylsulfoxide cream, and antineuropathic analgesics.
- Physiotherapy and behavioral therapy to address pain-related anxiety and movement avoidance.
- Interventional treatments such as spinal cord or dorsal root ganglion stimulation for refractory cases.
Main Results:
- The acute phase of CRPS is marked by immune system activation and inflammation.
- Central nervous system symptoms, including hyperalgesia and sensory disturbances, develop during the condition.
- Multidisciplinary treatment combining pharmacotherapy, physical therapy, behavioral therapy, and interventional options offers a comprehensive approach.
Conclusions:
- Stage-adapted, targeted treatment is essential for improving the prognosis of CRPS.
- A multidisciplinary approach is effective in managing the complex symptoms of CRPS.
- Early and appropriate intervention can mitigate the long-term impact of CRPS pain.
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