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Related Experiment Video

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Endosomal receptor trafficking: Retromer and beyond.

Jing Wang1, Alina Fedoseienko2,3, Baoyu Chen4

  • 1Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Pediatrics, Division of Neurology, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.

Traffic (Copenhagen, Denmark)
|April 19, 2018
PubMed
Summary

The retromer complex and its associated proteins regulate endosomal trafficking for cellular homeostasis. This review explores how retromer controls receptor recycling and how pathogens exploit this system.

Keywords:
WASHendosomereceptor traffickingretrieverretromersorting nexin

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The tubular endolysosomal network maintains cellular homeostasis through receptor trafficking.
  • Mammalian retromer is crucial for endosome-to-plasma membrane receptor recycling.
  • Associated molecules like WASH, SNXs, and TBC1d5 are key players in this process.

Purpose of the Study:

  • To review recent findings on retromer-mediated receptor trafficking.
  • To elucidate the mechanisms of retromer and its associated proteins.
  • To explore the role of this system in pathogen infection and disease.

Main Methods:

  • Literature review of recent studies on retromer and associated complexes.
  • Analysis of molecular interactions in receptor trafficking pathways.
  • Investigation of pathogen hijacking mechanisms.

Main Results:

  • Retromer facilitates diverse receptor recycling pathways.
  • SNXs directly interact with retromer cargo for retrieval.
  • A retromer-like complex, retriever, is involved in SNX17 cargo recycling.
  • Pathogens exploit endosomal sorting machinery.

Conclusions:

  • Retromer and its partners are central to endosomal sorting and cellular homeostasis.
  • Dysregulation of this pathway contributes to disease.
  • Understanding these mechanisms is vital for combating pathogen infections.