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Updated: Feb 11, 2026
08:22
Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
758
Frailty phenotypes and mortality after lung transplantation: A prospective cohort study
Jonathan P Singer1, Joshua M Diamond2, Michaela R Anderson3
1Department of Medicine, University of California, San Francisco, CA, USA.
Summary
Preoperative frailty, measured by the Short Physical Performance Battery (SPPB), significantly increases mortality risk in lung transplant recipients. Even a small decline in SPPB score raises the risk of death post-transplant.
Area of Science:
- Transplantation research
- Geriatric medicine
- Cardiopulmonary medicine
Background:
- Frailty is a known predictor of adverse outcomes in various clinical settings.
- Lung transplant candidates with frailty face higher mortality rates.
- Objective measurement of frailty is crucial for risk stratification in transplant patients.
Purpose of the Study:
- To determine the association between preoperative frailty, assessed by the Short Physical Performance Battery (SPPB), and mortality after lung transplantation.
- To evaluate the predictive value of frailty for long-term survival following lung transplantation.
Main Methods:
- A multicenter prospective cohort study involving 318 adult lung transplant recipients.
- Preoperative frailty assessed using the Short Physical Performance Battery (SPPB) and Fried Frailty Phenotype (FFP).
- Propensity score-adjusted Cox models and multivariate logistic regression were used to analyze the association between frailty and mortality.
Main Results:
- SPPB-defined frailty was significantly associated with increased 1-year (aHR: 7.5) and 4-year (aHR: 3.8) mortality.
- Each 1-point decrease in SPPB score correlated with a 20% increased risk of death (aHR: 1.20).
- FFP-defined frailty also predicted increased mortality within the first postoperative year (aHR: 3.8).
Conclusions:
- Preoperative frailty is a strong independent predictor of increased mortality risk after lung transplantation.
- The SPPB is a valuable tool for assessing frailty and predicting outcomes in lung transplant candidates.
- Identifying and potentially mitigating frailty may improve survival rates for lung transplant recipients.
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