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Updated: Feb 11, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Silica-Supported Catalyst for Enantioselective Arylation of Aldehydes under Batch and Continuous-Flow Conditions
Satoshi Watanabe1, Naoyuki Nakaya1, Junichiro Akai1
1Faculty of Molecular Chemistry and Engineering , Kyoto Institute of Technology , Matsugasaki, Sakyo-ku, Kyoto 606-8585 , Japan.
Abstract:
A silica-supported 3-aryl H8-BINOL-derived titanium catalyst exhibited high performance in the enantioselective arylation of aromatic aldehydes using Grignard and organolithium reagents not only under batch conditions but also under continuous-flow conditions. Even with a simple pipet reactor packed with the heterogeneous catalyst, the enantioselective production of chiral diarylmethanols could be achieved through a continuous introduction of aldehydes and mixed titanium reagents generated from the organometallic precursors. The pipet reactor could be used repeatedly in different reactions without appreciable deterioration of the activity.
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