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CD47 is a novel potent immunotherapy target in human malignancies: current studies and future promises

Bing Tong1, Mengzhao Wang1

  • 1Lung Cancer Center, Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China; Postal address: No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, PR China.

Future Oncology (London, England)
|April 19, 2018
PubMed

Insights

CD47 is a key immune checkpoint overexpressed in many cancers, acting as a "don't-eat-me" signal that prevents macrophage phagocytosis. Inhibitors targeting CD47 show promise for cancer immunotherapy, with ongoing clinical trials for various tumor types.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Immunosuppressive checkpoints like PD-L1, CTLA-4, and CD47 are crucial targets in cancer immunotherapy.
  • CD47, a 'marker-of-self' protein, is overexpressed across numerous tumor types, facilitating immune evasion.
  • CD47 functions as a potent macrophage immune checkpoint, inhibiting phagocytosis.

Purpose of the Study:

  • To review the role of CD47 as an immune checkpoint in cancer.
  • To discuss the therapeutic potential and challenges of CD47 inhibitors in cancer treatment.
  • To explore the application of CD47 inhibitors in both monotherapy and combination treatments.

Main Methods:

  • Literature review of studies on CD47 and cancer immunotherapy.
  • Analysis of CD47's mechanism as a 'don't-eat-me' signal.
  • Examination of clinical trial data for CD47 inhibitors.

Main Results:

  • CD47 overexpression broadly inhibits macrophage-mediated phagocytosis, promoting tumor immune evasion.
  • CD47 inhibitors present significant opportunities for cancer immunotherapy.
  • Ongoing clinical trials are evaluating CD47 inhibitors for hematological cancers and solid tumors.

Conclusions:

  • CD47 is a critical target for overcoming tumor immune evasion.
  • CD47 inhibitors offer a promising therapeutic strategy for various cancers.
  • Further research and clinical evaluation are essential for optimizing CD47-targeted therapies.
Keywords:
CD47CD47 blockadeSIRPanti-CD47 monoclonal antibodybispecific antibodycancerimmune checkpoint inhibitorimmunotherapyphagocytosistumor-associated macrophage

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