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Related Experiment Videos

Hypoxia does not increase CSF or plasma beta-endorphin activity.

A Freedman1, A T Scardella, N H Edelman

  • 1Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903-0019.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1988
PubMed
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Moderate and severe hypoxia do not increase endogenous opioids that affect breathing in adult goats. This suggests opioid involvement in hypoxia

Area of Science:

  • Respiratory physiology
  • Neuroendocrinology

Background:

  • Hypoxia, a state of low oxygen, can influence respiratory control.
  • Endogenous opioids are known to modulate physiological functions, including ventilation.

Purpose of the Study:

  • To investigate whether moderate and severe hypoxia stimulate the production of endogenous opioids that alter respiratory output in adult goats.

Main Methods:

  • Unanesthetized goats were exposed to 4 hours of moderate or severe hypoxia.
  • Ventilation, arterial blood gases, pH, and beta-endorphin activity in plasma and cerebrospinal fluid (CSF) were measured.
  • Naloxone, an opioid antagonist, was administered to some goats during severe hypoxia to assess opioid involvement.

Main Results:

  • Hypoxia increased ventilation as expected.

Related Experiment Videos

  • No significant changes in plasma or CSF beta-endorphin activity were observed after hypoxia.
  • Administration of naloxone did not alter the ventilatory response to severe hypoxia.

    • Conclusions:

    • Moderate and severe hypoxia do not appear to trigger the release of endogenous opioids that modify respiratory output in adult goats.
    • The previously observed opioid response to hypoxia in neonates may be a developmental phenomenon.