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Updated: Feb 11, 2026

Live Imaging of Chemokine Receptors in Zebrafish Neutrophils During Wound Responses
Published on: December 4, 2020
Insight on the regulation of chemokine activities
Valentina Cecchinato1, Mariagrazia Uguccioni1
1Laboratory of "Chemokines in Immunity", Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Abstract:
The activity of chemokines is regulated by several mechanisms that control the final cellular response. The present review discusses the complexity of the regulation of the chemokine system, and the novel findings describing how in persistent infections, the expression of chemokine receptors on the surface of T cells does not correlate with their homing potential. Thanks to the latest advances in our comprehension of the chemokine system, novel approaches targeting chemokines, chemokine receptors, or protein of their signaling pathway should be considered in order to achieve a personalized therapy.
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