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Chalkophores.

Grace E Kenney1, Amy C Rosenzweig1,2

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA; email: gkenney@u.northwestern.edu , amyr@northwestern.edu.

Annual Review of Biochemistry
|April 19, 2018
PubMed
Summary
This summary is machine-generated.

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Methanobactin (Mbn) are copper-binding molecules crucial for microbial copper homeostasis. This review explores Mbn function, biosynthesis, transport, and regulation, highlighting knowledge gaps in their production and handling in bacteria.

Area of Science:

  • Microbiology
  • Biochemistry

Background:

  • Copper-binding metallophores, or chalkophores, are vital for microbial copper homeostasis, similar to siderophores for iron.
  • Methanobactins (Mbns) are the best-studied chalkophores, identified as copper chelators for uptake in methane-oxidizing bacteria.

Purpose of the Study:

  • To review the current understanding of methanobactin (Mbn) function, biosynthesis, transport, and regulation.
  • To discuss other natural products involved in copper uptake and metallophores with copper-binding roles.

Main Methods:

  • Literature review of existing research on methanobactins and related copper-binding molecules.
  • Analysis of genomic evidence for Mbn production across diverse bacterial species.

Main Results:

Keywords:
bioinorganic chemistrychalkophorecopper homeostasismetallophoremethanobactinnatural productsiderophore

Related Experiment Videos

  • Mbns are ribosomally produced, post-translationally modified natural products essential for copper uptake in certain bacteria.
  • Genomic data suggests Mbn production is more widespread than previously known.
  • While some protein functions in Mbn processes are supported by evidence, significant gaps in knowledge persist.

    • Conclusions:

    • Methanobactins are key players in microbial copper homeostasis, with their production potentially more common across bacteria.
    • Further research is needed to elucidate the complete mechanisms of Mbn synthesis, transport, and regulation.