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Reduced longitudinal cardiac strain in asthma patients
I Tuleta1, N Eckstein1, F Aurich1
1a Department of Internal Medicine II - Cardiology, Pulmonology and Angiology , University of Bonn , Bonn , Germany.
Summary
Allergic asthma, particularly severe cases, is linked to subclinical heart dysfunction. Speckle-tracking analysis reveals impaired left and right ventricular function in asthma patients compared to controls.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Asthma is a chronic respiratory disease with potential systemic effects.
- The relationship between asthma and cardiac function, especially subclinical dysfunction, requires further investigation.
Purpose of the Study:
- To investigate the association between allergic asthma and manifest or subclinical heart dysfunction.
- To evaluate cardiac function using standard echocardiography and speckle-tracking analysis in asthma patients.
Main Methods:
- Seventy-two asthma patients (mild-to-moderate and severe) and 20 controls underwent echocardiography.
- Global longitudinal left and right ventricular strains were assessed using speckle-tracking.
- Biomarkers including NT-pro-BNP, IgE, and CRP were measured.
Main Results:
- Reduced longitudinal left ventricular strain was observed in both mild-to-moderate and severe asthma groups.
- Severe asthma showed significantly decreased longitudinal right ventricular strain.
- Elevated CRP, IgE, and eosinophils were noted in asthma patients compared to controls.
Conclusions:
- Allergic asthma, especially severe forms, is associated with subclinical impairment of left and right ventricular function.
- Speckle-tracking analysis is a valuable tool for detecting early cardiac dysfunction in asthma.
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