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Metastatic epithelioid trophoblastic tumor of the lung: A case report
Wangjun Lei1, Fangbiao Zhang, Chunhui Zheng
1Department of Radiology, Suichang People's Hospital, Suichang Department of Cardiothoracic Surgery, Zhejiang University, Lishui Central Hospital, Lishui, Zhejiang, P.R. China.
Rationale:
Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women.
Patient Concerns:
Here we describe a 50-year-old woman with a metastatic ETT of the lung showing increasing tracer uptake at PET/CT.
Diagnosis:
Hematoxylin-eosin staining showed a tumor composed of nests of epithelioid cells with necrotic debris and peritumoral hyaline-like material. Immunohistochemical staining of the tumor cells was positive for human chorionic gonadotropin (HCG) and cytokeratin 18.
Interventions:
The patient underwent thoracoscopic lower left lobectomy combined with mediastinal lymphadenectomy. At surgery, a solid mass (size 3.0 × 3.0 cm) was found in the left lower lung.
Outcomes:
The patient was discharged on the tenth day postsurgery, following an uneventful recovery. Three months postsurgery, the patient was asymptomatic and is currently being managed with close follow-up.
Lessons:
Metastatic ETT of lung is a very rare disease. Complete surgical resection and chemotherapy may be the critical therapeutic option.
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