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Impact of bone marrow mononuclear cells therapy on left ventricular function in patients with ST-elevated myocardial

Chao Wang1, Xiujiang Han, Yongjian Li

  • 1Department of Cardiology, Tianjin Nankai Hospital, Tianjin, China.

Medicine
|April 19, 2018
PubMed

Insights

Bone marrow mononuclear cell therapy shows promise for ST-elevated myocardial infarction (STEMI) patients. This cell therapy improved infarct size and myocardial perfusion, though left ventricular function showed no significant change.

Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Interventional Cardiology

Background:

  • Bone marrow mononuclear cell (BMMNC) therapy is explored as an adjunct for ST-elevated myocardial infarction (STEMI).
  • The efficacy of BMMNC therapy in STEMI patients remains debated.
  • This meta-analysis evaluates cell therapy's impact on left ventricular function post-STEMI.

Purpose of the Study:

  • To assess the therapeutic effect of BMMNC therapy on left ventricular function in STEMI patients.
  • To evaluate changes in infarct size and myocardial perfusion following cell therapy.
  • To synthesize evidence from randomized controlled trials on BMMNC therapy in STEMI.

Main Methods:

  • Systematic literature search of PubMed and EMBASE databases up to 2017.
  • Inclusion of randomized controlled trials comparing BMMNC therapy with control in STEMI patients undergoing percutaneous coronary intervention.
  • Primary endpoints included wall motion score index, infarct size, wall thickening, and myocardial perfusion.

Main Results:

  • Analysis of 24 trials involving 1536 patients.
  • BMMNC therapy significantly reduced infarct size (P=.007) and improved myocardial perfusion (P<.001).
  • No significant differences were observed in wall motion score index or wall thickening between groups.

Conclusions:

  • Intracoronary BMMNC infusion is a safe adjunctive treatment for STEMI.
  • Cell therapy demonstrates benefits in reducing infarct size and enhancing myocardial perfusion.
  • Further multicenter randomized trials are warranted to confirm therapeutic efficacy.
Abstract

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