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Updated: Feb 11, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

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The human clone ST22 SCCmec IV methicillin-resistant Staphylococcus aureus isolated from swine herds and wild

Marilyn C Roberts1, Prabhu Raj Joshi2, Alexander L Greninger3

  • 1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.

FEMS Microbiology Ecology
|April 19, 2018
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) ST22 SCCmec IV was detected in healthy pigs and macaques in Nepal. This marks the first isolation of this specific MRSA strain from livestock and primates, highlighting potential One Health concerns.

Area of Science:

  • Microbiology
  • Genomics
  • Veterinary Medicine

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health concern.
  • Surveillance of MRSA in animal populations, particularly livestock and non-human primates, is crucial for understanding transmission dynamics.

Purpose of the Study:

  • To investigate the prevalence and characteristics of MRSA in swine and wild macaques in Nepal.
  • To identify specific MRSA strains, their genetic makeup, and antibiotic resistance profiles.

Main Methods:

  • Collection and processing of nasal swabs from swine and saliva samples from macaques.
  • Isolation and identification of MRSA using selective media and biochemical tests.
  • Characterization of MRSA isolates using SCCmec typing, multilocus sequence typing (MLST), whole genome sequencing (WGS), and antibiotic susceptibility testing.

Main Results:

  • MRSA was detected in 6.8% of macaques and 2.1% of swine.
  • The predominant MRSA strain identified was ST22 SCCmec type IV, found in both species.
  • Genomic analysis revealed specific mutations conferring resistance to ciprofloxacin and linezolid, as well as the presence of various resistance and virulence genes.

Conclusions:

  • This study reports the first isolation of MRSA ST22 SCCmec IV from both livestock (swine) and non-human primates (macaques) in Nepal.
  • The findings underscore the potential for interspecies transmission of MRSA and emphasize the importance of One Health approaches in surveillance and control efforts.

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