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Does health informatics have a replication crisis?

Enrico Coiera1, Elske Ammenwerth2, Andrew Georgiou1

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Replication studies are rare in health informatics due to context effects. Embracing replication enhances research rigor and strengthens the evidence base for this discipline.

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Area of Science:

  • Biomedical and Health Informatics
  • Psychology
  • Basic Medical Sciences

Background:

  • Research reproducibility is a significant challenge across various scientific fields.
  • Biomedical and health informatics faces similar challenges regarding the reproducibility of published studies.

Purpose of the Study:

  • To explore the concept of replication within informatics.
  • To identify and discuss the unique challenges to replication in this discipline.

Main Methods:

  • A narrative review of recent literature on research replication challenges was conducted.

Main Results:

  • Experimental replication studies are uncommon in informatics, despite growing interest in data re-analysis.
  • Context effects pose a substantial challenge, impacting replication fidelity as interventions vary across settings.
  • Replication studies offer diverse designs (exact, partial, quasi, conceptual) to assess validity and generalizability.

Conclusions:

  • Poor replication weakens the quality of research and the evidence-based foundation of health informatics.
  • Replication increases research rigor and aids in developing methods to differentiate context impact from inherent nonreproducibility.
  • Prioritizing replication is crucial for establishing biomedical and health informatics as an evidence-based discipline.