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Updated: Feb 11, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Inorganic hydrogen polysulfides: chemistry, chemical biology and detection
Heng Liu1,2, Miles N Radford2, Chun-Tao Yang3
1Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, China.
Abstract:
Recent studies suggest that inorganic hydrogen polysulfides (H2 Sn , n ≥ 2) play important regulatory roles in redox biology. Modulation of their cellular levels could have potential therapeutic value. This review article focuses on our current understanding of the biosynthesis, biofunctions, fundamental physical/chemical properties, detection methods and delivery techniques of H2 Sn . LINKED ARTICLES: This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc.
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