Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

460
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
460
Behavior Therapy01:22

Behavior Therapy

732
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
732
Drug Therapy01:28

Drug Therapy

304
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
304
Cognitive Therapy01:25

Cognitive Therapy

1.3K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.3K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.3K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual-Functional Antibiotic Adjuvants Based on Antibacterial Polyesters With Guanidinium and Boronic Acid Motifs.

Macromolecular bioscience·2026
Same author

Highly Efficient Thiol-Michael Addition Post-Modification toward Potent Degradable Antibacterial Polyesters with Guanidine Moiety.

Biomacromolecules·2025
Same author

Photochemical [2 + 2] Cycloaddition Enables the Synthesis of Highly Thermally Stable and Acid/Base-Resistant Polyesters from a Nonpolymerizable α,β-Conjugated Valerolactone.

ACS macro letters·2024
Same author

Thermally Stable and Chemically Recyclable Poly(ketal-ester)s Regulated by Floor Temperature.

Journal of the American Chemical Society·2024
Same author

Enabling Closed-Loop Circularity of "Non-Polymerizable" α, β-Conjugated Lactone Towards High-Performance Polyester with the Assistance of Cyclopentadiene.

Angewandte Chemie (International ed. in English)·2024
Same author

Synthesis and antibacterial properties of fluorinated biodegradable cationic polyesters.

Journal of materials chemistry. B·2024

Related Experiment Video

Updated: Feb 11, 2026

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

9.4K

ROS-Responsive Chalcogen-Containing Polycarbonates for Photodynamic Therapy.

Li Yu1, Yue Yang1, Fu-Sheng Du1

  • 1Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Department of Polymer Science and Engineering, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , China.

Biomacromolecules
|April 19, 2018
PubMed
Summary

This study introduces novel reactive oxygen species (ROS)-responsive aliphatic polycarbonates that form nanoparticles. These nanoparticles degrade in response to hydrogen peroxide (H2O2), enabling controlled release of anticancer drugs and photosensitizers for photodynamic therapy.

More Related Videos

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.9K
Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

532

Related Experiment Videos

Last Updated: Feb 11, 2026

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

9.4K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.9K
Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
07:24

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

Published on: September 12, 2025

532

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanomedicine

Background:

  • Reactive oxygen species (ROS)-responsive polymers are promising for photodynamic therapy (PDT).
  • Developing precise control over nanoparticle degradation is crucial for drug delivery systems.

Purpose of the Study:

  • To synthesize and characterize novel ROS-responsive aliphatic polycarbonates.
  • To investigate their self-assembly into nanoparticles and triggered degradation mechanisms.
  • To evaluate their potential as a nanoplatform for co-delivery of chemotherapeutics and photosensitizers.

Main Methods:

  • Ring-opening polymerization (ROP) of cyclic carbonate monomers containing selenide or telluride groups.
  • Preparation of amphiphilic block copolymers and their self-assembly into nanoparticles.
  • Investigation of H2O2-induced oxidation and degradation kinetics using 1H NMR.
  • Loading of chlorin e6 (photosensitizer) and doxorubicin (anticancer drug).
  • In vitro cytotoxicity assays on MCF-7 cells.

Main Results:

  • Controlled anionic ROP yielded ROS-responsive aliphatic polycarbonates.
  • Amphiphilic block copolymers formed stable nanoparticles (∼100 nm) that rapidly dissociated upon H2O2 exposure.
  • Degradation rates varied, with telluride-containing nanoparticles degrading fastest and phenyl selenide-based ones slowest.
  • Co-loaded nanoparticles demonstrated light-triggered payload release and synergistic cytotoxicity against MCF-7 cells.

Conclusions:

  • Novel ROS-responsive polycarbonates were successfully synthesized and formed functional nanoparticles.
  • The nanoparticles exhibit tunable degradation in response to ROS, enabling controlled drug release.
  • The developed nanoplatform shows significant potential for combined photodynamic therapy and chemotherapy.