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Published on: January 28, 2019
Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa
Jacqueline E Tate1, Jason M Mwenda1, George Armah1
1From the Centers for Disease Control and Prevention, Atlanta (J.E.T., M.M.C., B.A.L., C.Y., H.G., U.D.P.); the World Health Organization (WHO) Regional Office for Africa, Brazzaville, Republic of Congo (J.M.M., R.M., F.R.Z., R.M.M.); the Noguchi Memorial Institute for Medical Research (G.A.) and the School of Medicine and Dentistry, College of Health Sciences (C.E.-L.), University of Ghana, and Korle Bu Teaching Hospital (H.G.-A.), Accra, Komfo Anokye Teaching Hospital, Kumasi (D.A.), and the School of Public Health, University of Health and Allied Sciences, Hohoe (C.T.N.) - all in Ghana; the WHO Country Office (B.J.) and Muhimbili National Hospital (M.M.), Dar es Salaam, Kilimanjaro Christian Medical Center, Moshi (D.M.), and Mbeya Zonal Referral Hospital, Mbeya (L.M.) - all in Tanzania; Kenya Medical Research Institute, Center for Global Health Research, Kisumu (R.O., B.O.), the Department of Surgery, School of Medicine, University of Nairobi, Nairobi (F.O.), and the School of Medicine, Moi University, Eldoret (P.S.) - all in Kenya; the WHO Country Office (A.A., T.K., F.T.) and the School of Medicine, Addis Ababa University (A.T.), Addis Ababa, Ethiopia; Harare Central Hospital (H.M., B.M.), the Department of Pediatrics and Child Health, University of Zimbabwe (H.M.), the WHO Intercountry Support Team (G.W.), and Epidemiology and Disease Control, Ministry of Health and Child Care (P.M.), Harare, Zimbabwe; the Children's Hospital (E.M.), Adult Hospital, Virology Laboratory (J.S.), and Adult Hospital, Department of Surgery, Pediatric Surgical Unit (B.B.), University Teaching Hospitals, Lusaka, Zambia; the College of Medicine, University of Malawi, Blantyre (B.N.); and the Centre for Global Vaccine Research, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom (N.C.).
Background:
Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries.
Methods:
Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria. Rotavirus vaccination status was confirmed by review of the vaccine card or clinic records. The risk of intussusception within 1 to 7 days and 8 to 21 days after vaccination among infants 28 to 245 days of age was assessed by means of the self-controlled case-series method.
Results:
Data on 717 infants who had intussusception and confirmed vaccination status were analyzed. One case occurred in the 1 to 7 days after dose 1, and 6 cases occurred in the 8 to 21 days after dose 1. Five cases and 16 cases occurred in the 1 to 7 days and 8 to 21 days, respectively, after dose 2. The risk of intussusception in the 1 to 7 days after dose 1 was not higher than the background risk of intussusception (relative incidence [i.e., the incidence during the risk window vs. all other times], 0.25; 95% confidence interval [CI], <0.001 to 1.16); findings were similar for the 1 to 7 days after dose 2 (relative incidence, 0.76; 95% CI, 0.16 to 1.87). In addition, the risk of intussusception in the 8 to 21 days or 1 to 21 days after either dose was not found to be higher than the background risk.
Conclusions:
The risk of intussusception after administration of monovalent human rotavirus vaccine was not higher than the background risk of intussusception in seven lower-income sub-Saharan African countries. (Funded by the GAVI Alliance through the CDC Foundation.).
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