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An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential

Joachim Michael Matz1, Christian Goosmann2, Kai Matuschewski3

  • 1Department of Molecular Parasitology, Institute of Biology, Humboldt University, Philippstraße 13, 10115 Berlin, Germany; Parasitology Unit, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany; Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Cell Reports
|April 19, 2018
PubMed
Summary

A novel malaria parasite protein, PHBL, is essential for mitochondrial function and parasite development. PHBL deficiency impairs Plasmodium berghei fitness and blocks transmission to mosquitoes.

Keywords:
Plasmodium bergheiSPFHmalariamembrane potentialmitochondrionookineteprohibitinstomatin-like proteintransmission

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