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DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
Published on: October 8, 2019
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LncRNA Expression Profile of Human Thoracic Aortic Dissection by High-Throughput Sequencing
Jie Sun1,2, Guojun Chen1, Yuanwen Jing1
1State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Summary
This study investigated long non-coding RNA (lncRNA) expression in human thoracic aortic dissection (TAD). Dysregulated lncRNAs were identified, suggesting their potential as therapeutic targets for TAD.
Area of Science:
- Cardiovascular Biology
- Molecular Genetics
- Genomics
Background:
- Thoracic aortic dissection (TAD) is a life-threatening cardiovascular disease.
- The role of long non-coding RNAs (lncRNAs) in TAD pathogenesis remains largely unexplored.
Purpose of the Study:
- To investigate the lncRNA expression profile in human TAD.
- To identify dysregulated lncRNAs and predict their potential functions in TAD.
Main Methods:
- High-throughput sequencing of human TAD and normal aortic tissues.
- Bioinformatics analysis for lncRNA role prediction.
- Quantitative real-time polymerase chain reaction (qRT-PCR) for validation.
Main Results:
- Identification of 269 aberrantly expressed lncRNAs and 2,255 mRNAs in TAD.
- Validation of five dysregulated genes using qRT-PCR.
- Construction of lncRNA-mRNA coexpression networks and lncRNA-miRNA-mRNA interactions, including XIST, p21, and RUNX1.
Conclusions:
- A distinct lncRNA expression profile characterizes human TAD.
- Dysregulated lncRNAs, such as XIST, are implicated in TAD.
- lncRNAs represent promising novel therapeutic targets for human TAD.
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