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Updated: Feb 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Transfusion-Transmitted Infections: an Update on Product Screening, Diagnostic Techniques, and the Path Ahead
Christina L Dean1, Jenna Wade2, John D Roback2
1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA cdean6@emory.edu.
Abstract:
The mandated testing of blood components for infectious diseases, to prevent transfusion-transmitted infections (TTIs), began in the 1950s. Since then, changes in predonation questionnaires and advances in testing techniques have afforded more sensitive and specific tests for pathogens, in addition to allowing earlier detection. Given that these approaches have very low but detectable failure rates, the recent development and implementation of proactive pathogen reduction approaches is the new forefront of TTI prevention strategies. With globalization and the ability of pathogens to evolve rapidly, continuous redefining of testing standards and laboratory techniques is paramount for maintaining a safe blood supply.
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