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lncRNA - Long Non-coding RNAs02:39

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Long Non-Coding RNAs in Neuronal Aging.

Diana Pereira Fernandes1, Mainá Bitar2, Frank M J Jacobs3

  • 1University of Amsterdam, Swammerdam Institute for Life Sciences (SILS), 1098XH Amsterdam, The Netherlands. d.s.pereirafernandes@uva.nl.

Non-Coding RNA
|April 20, 2018
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial for brain function. Dysregulation of these molecules in aging brains contributes to neurodegeneration and impacts neuronal processes like neurogenesis.

Keywords:
age-related diseasesagingantisense transcriptcognitionlncRNAsneurodegenerationneurogenesisnuclear architecturetransposable element

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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in complex regulatory networks.
  • lncRNA dysregulation is linked to aging and neurodegenerative diseases, highlighting their importance in neuronal function.

Purpose of the Study:

  • To review the function and expression of neuronal-associated lncRNAs.
  • To explore the impact of lncRNAs on epigenetic changes, transposable elements, and nuclear architecture in neurons.
  • To discuss the role of lncRNAs in age-related neurodegeneration and their potential effects on neurogenesis and synaptic plasticity.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs in the brain.
  • Analysis of lncRNA involvement in epigenetic modifications and 3D nuclear organization.
  • Discussion of molecular mechanisms linking lncRNA dysregulation to protein aggregation and neurodegeneration.

Main Results:

  • lncRNAs play significant roles in neuronal processes, including higher-order cognition.
  • Dysregulated lncRNA expression in aging brains is associated with epigenetic alterations and compromised nuclear architecture.
  • lncRNAs may promote neurodegeneration through protein aggregation and affect neurogenesis and synaptic plasticity.

Conclusions:

  • lncRNAs are critical regulators in the aging brain, with their dysregulation contributing to neurodegenerative pathogenesis.
  • Age-related changes in lncRNA expression can disrupt the genomic and epigenetic landscape of neurons.
  • Targeting lncRNAs may offer therapeutic avenues for age-related neurological disorders.