Proton-decoupled carbon magnetic resonance spectroscopy in human calf muscles at 7 T using a multi-channel...

¹³C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of ¹³C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and ¹H decoupling, which leads to a simplified spectral pattern. ¹H-decoupled ¹³C-MRS requires RF coils which support both, ¹H and ¹³C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies. We present the development, evaluation, and first in vivo measurement with a 7 T 3-channel ¹³C and 4-channel ¹H transceiver array optimized for ¹H-decoupled ¹³C-MRS in the posterior human calf muscles. To ensure minimal cross-coupling between ¹³C and ¹H arrays, several strategies were combined: mutual magnetic flux was minimized by coil geometry, two LCC traps were inserted into each ¹³C element, and band-pass and low-pass filters were integrated along the signal pathways. The developed coil array was successfully tested in phantom and in vivo MR experiments, showing a simplified spectral pattern and increase in signal-to-noise ratio of approximately a factor 2 between non-decoupled and ¹H-decoupled spectra in a glucose phantom and the human calf muscle.