Fluid-Attenuated Inversion Recovery Signal Intensity as a Predictor of Gadolinium Enhancement in Relapsing-Remitting

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Updated: Feb 11, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.1K

Mihail Guranda, Marco Essig, Ariane Poulin

    International Journal of MS Care
    |April 20, 2018
    PubMed
    Abstract

    Insights

    Ultrabright lesions on MRI scans in relapsing-remitting multiple sclerosis (RRMS) are linked to gadolinium enhancement. This finding holds true for both qualitative and quantitative assessments, aiding in disease monitoring.

    Area of Science:

    • Radiology
    • Neuroscience
    • Medical Imaging

    Background:

    • Magnetic resonance imaging (MRI) is crucial for diagnosing and monitoring relapsing-remitting multiple sclerosis (RRMS).
    • The study investigates "ultrabright" axial fluid-attenuated inversion recovery (FLAIR) lesions and their relationship with gadolinium enhancement in RRMS patients.

    Purpose of the Study:

    • To explore the association between "ultrabright" axial FLAIR lesions and gadolinium enhancement in RRMS.
    • To utilize both qualitative and quantitative approaches to analyze this association.

    Main Methods:

    • Review of MRI scans from RRMS patients (2010-2015).
    • Independent identification of ultrabright lesions on axial FLAIR sequences by two radiologists.
    • Measurement of contrast-to-noise ratio (CNR) for ultrabright and control lesions.

    Main Results:

    • Out of 301 lesions, 77 (26%) were identified as ultrabright by both radiologists, showing moderate interrater agreement (κ = 0.77).
    • Ultrabright lesions showed a significant association with gadolinium enhancement (χ² = 30.8, P < .001).
    • Higher CNR values correlated with gadolinium enhancement in both 1.5-T and 3-T MRI studies, with good diagnostic accuracy.

    Conclusions:

    • Both qualitative and quantitative identification of ultrabright axial FLAIR lesions are significantly associated with gadolinium enhancement in RRMS.
    • This association aids in understanding disease activity and monitoring progression.

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