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Nrf2-Mediated Metabolic Reprogramming in Cancer

Yan-Yang Wang1,2, Juan Chen3, Xiao-Ming Liu4

  • 1Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.

Oxidative Medicine and Cellular Longevity
|April 20, 2018
PubMed

Insights

The Nrf2 pathway regulates cancer metabolism, influencing tumor growth and treatment resistance. Understanding this link may lead to new cancer biomarkers and therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background:

  • Metabolic reprogramming is a key feature of cancer.
  • The Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is crucial for cellular defense against oxidative stress.
  • Emerging evidence highlights the role of Nrf2 in cancer metabolism.

Purpose of the Study:

  • To review the role of Nrf2 in cancer metabolic reprogramming.
  • To highlight Nrf2's influence on malignant transformation, proliferation, and treatment resistance.
  • To discuss potential future applications in cancer diagnostics and therapeutics.

Main Methods:

  • Literature review of studies on Nrf2 and cancer metabolism.
  • Analysis of Nrf2-mediated metabolic pathways in cancer.
  • Synthesis of current knowledge on Nrf2's impact on cancer progression and therapy.

Main Results:

  • Nrf2 significantly impacts cancer cell metabolism.
  • Nrf2 activation promotes metabolic adaptations supporting cancer growth.
  • Nrf2 plays a role in developing resistance to cancer treatments.

Conclusions:

  • Nrf2-directed metabolic reprogramming is central to cancer development.
  • Targeting Nrf2 offers potential for novel cancer therapies.
  • Further research may yield noninvasive biomarkers for Nrf2-driven cancers.

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