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Updated: Feb 11, 2026

An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy
Thumuganti Gayathri1,2, A Vijayalakshmi3, Sreejith Mangalath4
1Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal road, Tarnaka, Hyderabad-500007, India.
Abstract:
We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC50 values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC50 = 0.39 μM) under similar experimental conditions.
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