Related Experiment Video
Updated: Feb 11, 2026
09:01
Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
18.0K
Organoid and Enteroid Modeling of Salmonella Infection
Yuebang Yin1, Daoguo Zhou2,3
1Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
Frontiers in Cellular and Infection Microbiology
|April 20, 2018
Summary
Salmonella infections cause significant public health issues. Enteroids and induced intestinal organoids offer advanced models for studying bacterial-host interactions, overcoming limitations of traditional methods.
Area of Science:
- Microbiology
- Infectious Diseases
- Host-Pathogen Interactions
Background:
- Salmonella bacteria cause salmonellosis, a significant global health concern.
- Traditional infection models like cell lines and animal models have limitations in fully replicating human infections.
- Rising antibiotic resistance necessitates better understanding of Salmonella virulence mechanisms.
Purpose of the Study:
- To review the utility of emerging organoid models for studying Salmonella infections.
- To compare enteroids and induced intestinal organoids as infection models.
- To highlight the advantages of organoids over conventional models.
Main Methods:
- Review of existing literature on Salmonella infection models.
- Comparison of enteroids (epithelial cells) and induced intestinal organoids (including mesenchymal cells).
- Evaluation of organoid architecture and mimicry of in vivo intestinal structures.
Main Results:
- Enteroids and induced intestinal organoids closely mimic the architecture of the in vivo intestine.
- These organoid models provide a more accurate representation of host-pathogen interactions compared to traditional models.
- Induced intestinal organoids contain mesenchymal cells, while enteroids consist solely of epithelial cells.
Conclusions:
- Enteroids and induced intestinal organoids are promising models for Salmonella research.
- These advanced models can help elucidate molecular mechanisms of Salmonella infection.
- Organoid technology represents a significant advancement in studying bacterial-host interactions.
Related Concept Videos
01:20Infection
12.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.8K
01:26Stages of Infection
65.5K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.5K
01:26Defense Mechanism Against Infection
9.8K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.8K
01:26Sexually Transmitted Infections
1.2K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.2K
01:26Factors Affecting the Risk of Infection
13.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.8K
01:26Urinary Tract Infection I: Introduction
740
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
740